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Understanding Side Effects

Signifor® LAR (pasireotide) for injectable suspension

When it comes to side effects, each person may have a different experience. Signifor LAR may cause serious side effects, such as:

  • Treatment with Signifor LAR may cause high blood sugar levels (hyperglycemia) and diabetes. Your health care provider should check your blood sugar level before you start receiving Signifor LAR and while you receive it. Tell your health care provider if you have any of these symptoms:
    • Excessive thirst
    • Urinate more than usual
    • Increased appetite with weight loss
    • Tiredness
    If you get hyperglycemia, your health care provider may give you medicine to lower your blood sugar. Your health care provider may also change your dose of Signifor LAR or ask you to stop receiving it.
  • Slow heart rate (bradycardia). Signifor LAR can cause your heart to beat slower. People who have, or have had heart problems, or take certain medicines used to treat slow heart rate or that may cause a slow heart rate, are at higher risk for bradycardia. Tell your health care provider if you get any of these symptoms:
    • Weakness
    • Dizziness
    • Fainting or near fainting spells
  • Changes in the electrical system of your heart (QT interval prolongation). Tell your health care provider if you get any of these symptoms:
    • Weakness
    • Dizziness
    • Fainting or near fainting spells
  • Higher than normal liver function tests. Your health care provider should do blood tests to check your liver while you receive Signifor LAR.
  • Gallstones (cholelithiasis). Tell your health care provider if you get any of these symptoms:
    • Sudden pain in your upper right stomach area (abdomen)
    • Sudden pain in your right shoulder or between your shoulder blades
    • Yellowing of your skin and whites of your eyes
    • Fever with chills
    • Nausea
  • Low levels of pituitary hormones (pituitary insufficiency). Signifor LAR may reduce the pituitary hormones in your body. Your health care provider should do a blood test to check your pituitary hormone levels before you start receiving Signifor LAR and while you receive it.

Tell your health care provider if you get any of these symptoms:

  • Nausea and vomiting
  • Tiredness
  • Dizziness
  • Diarrhea
  • Low blood glucose levels
  • Loss of appetite
  • Weight loss

The most common side effects of Signifor LAR include:

  • Diarrhea
  • Gallstones (cholelithiasis)
  • High blood sugar (hyperglycemia)
  • Diabetes mellitus

Tell your health care provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Signifor LAR. For more information, ask your health care provider or pharmacist, or view the full prescribing information for Signifor LAR.

Most patients experience side effects at some time. Always report your experience to your physician. You are also encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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