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Before you receive Signifor® LAR (pasireotide) for injectable suspension for the first time, your health care provider should do a blood test to check your fasting blood sugar level, electrolyte levels, and your liver function, and check your heart (electrocardiogram).
The recommended starting dose of Signifor LAR is a 40 mg injection into the muscle of the buttocks, once every 4 weeks (every 28 days). Signifor LAR must be given by a trained health care provider.
The recommended initial dose for patients with moderately impaired hepatic function (Child-Pugh B) is 20 mg every 4 weeks and the maximum recommended dose is 40 mg every 4 weeks. You should not use Signifor LAR if you have severe hepatic impairment (Child-Pugh C).
If GH and IGF-1 levels have not returned to normal after 3 months of treatment with Signifor LAR at 40 mg but your body is reacting well to the medication, your doctor may decide to increase the dose to 60 mg.
In the same way, if your body is not reacting well to the treatment, or if GH and IGF-1 levels fall below normal, your doctor may decrease your dose, either temporarily or permanently, in amounts of 20 mg.
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